Natural Progesterone Capsules 100Mg 200Mg Steroid Based Hormones
Product : Progesterone Capsules
Specification : 50mg, 100mg, 200mg
Standard : In - house
Packing : 10’s/blister
Progesterone is a major progestational steroid that is secreted
primarily by the corpus luteum and the placenta. Progesterone acts
on the uterus, the mammary glands, and the brain. It is required in
embryo implantation, pregnancy maintenance, and the development of
mammary tissue for milk production. Progesterone, converted from
pregnenolone, also serves as an intermediate in the biosynthesis of
gonadal steroid hormones and adrenal corticosteroids.
For progesterone supplementation or replacement as part of an
Assisted Reproductive Technology (ART) treatment for infertile
women with progesterone deficiency and for the treatment of
secondary amenorrhea. Also used for the reduction of the incidence
of endometrial hyperplasia and the attendant risk of endometrial
carcinoma in postmenopausal women receiving estrogen replacement
therapy, as well as treatment of abnormal uterine bleeding due to
hormonal imbalance in the absence of organic pathology such as
fibroids or uterine cancer.
Progesterone is a naturally occuring progestin or a synthetic form
of the naturally occurring female sex hormone, progesterone. In a
woman's normal menstrual cycle, an egg matures and is released from
the ovaries (ovulation). The ovary then produces progesterone,
preventing the release of further eggs and priming the lining of
the womb for a possible pregnancy. If pregnancy occurs,
progesterone levels in the body remain high, maintaining the womb
lining. If pregnancy does not occur, progesterone levels in the
body fall, resulting in a menstrual period. Progesterone tricks the
body processes into thinking that ovulation has already occurred by
maintaining high levels of the synthetic progesterone. This
prevents the release of eggs from the ovaries.
Mechanism of action
Progesterone shares the pharmacological actions of the progestins.
Progesterone binds to the progesterone and estrogen receptors.
Target cells include the female reproductive tract, the mammary
gland, the hypothalamus, and the pituitary. Once bound to the
receptor, progestins like Progesterone will slow the frequency of
release of gonadotropin releasing hormone (GnRH) from the
hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone)
surge. In women who have adequate endogenous estrogen, progesterone
transforms a proliferative endometrium into a secretory one.
Progesterone is essential for the development of decidual tissue
and is necessary to increase endometrial receptivity for
implantation of an embryo. Once an embryo has been implanted,
progesterone acts to maintain the pregnancy. Progesterone also
stimulates the growth of mammary alveolar tissue and relaxes
uterine smooth muscle. It has little estrogenic and androgenic