CLIA Reagents of Hypertension (Angiotensin II- human)

^{Angiotensin II is a polypeptide substance produced by the hydrolysis of angiotensin I under the action of angiotensin-converting enzyme.}

^{Angiotensin receptors are present in vascular smooth muscle, cells of the adrenal cortex, and cells in some parts of the brain, heart and kidney organs.}

^{Angiotensin II binds to angiotensin receptors, causing corresponding physiological effects, including}

^{(1) constricting systemic arterioles and veins, increasing blood pressure, and increasing blood return to the heart;}

^{(2) increasing the release of sympathetic vasoconstrictor fiber transmitters;}

^{(3) making Sympathetic vasoconstrictor center tension;}

^{(4) stimulate adrenal synthesis and release of aldosterone;}

^{(5)cause or enhance thirst, leading to drinking behavior.}

^{Angiotensin II in plasma is usually determined by radioimmunoassay. At present, the detection of angiotensin Ⅱ in plasma has become an important index for the diagnosis, treatment and research of primary and secondary hypertension. It is of great significance for the diagnosis, treatment and pathogenesis of kidney disease}

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