Stainless Steel Multi Effect Falling Film Evaporator For Pharmaceutical
Price:
100,000USD~2,500,000USD/SET
MOQ:
1 set
Delivery Time:
3 months
Brand:
HANPU
Product Description
Stainless Steel Multi-Effect Falling Film Evaporator for Pharmaceutical
Crafted for GMP-compliant production lines, our stainless-steel multi-effect falling film evaporator concentrates heat-sensitive APIs, intermediates, syrups, and solvent-containing streams with low residence time and excellent batch-to-batch consistency. Features hygienic SS316L product contact surfaces, automated CIP/SIP, and validated documentation to meet FDA/EMA expectations while reducing steam consumption and cooling demand.
Working Principle
Feed is distributed evenly at the top of each effect and forms a thin film inside the tubes. Under vacuum, the film boils at reduced temperature. Vapor from the upstream effect heats the downstream effect, cascading energy to achieve a high steam economy. Cyclone separators ensure low carryover, while condensate is recovered as clean utility water.
Key Features
- Hygienic by Design: SS316L product side, orbital welding, polished tube ID/OD, sloped drains, sanitary valves, and dead-leg control
- Quality & Compliance: GMP-oriented design with DQ/IQ/OQ support, material traceability, calibration records, and FAT/SAT protocols
- Product Integrity: Short residence time and low-temperature operation protect actives, color, aroma, and viscosity
- Energy Efficient: Multi-effect heat reuse; optional TVR to boost steam economy and reduce OPEX
Process Overview
- Preheat & distribution: Feed preheated via condensate/plate exchanger and evenly distributed to tube bundle
- Effect 1 -> n: Falling-film evaporation under vacuum; vapor from previous effect used as heating medium
- Separation: High-efficiency mist eliminators minimize entrainment and ensure clean condensate
- Condensation & vacuum: Surface condenser with vacuum pump ejects non-condensables; clean condensate recovered
- Automation & control: PLC/HMI with recipes, trends, alarms; inline °Brix/density (where applicable), flow, level, P/T
- CIP/SIP: Automated cycles (alkaline/acid/hot water) and optional steam-in-place for validated cleaning
Technical Specifications
| Item | Typical Range / Note |
|---|---|
| Evaporation capacity | 0.5-20 t/h per train (scalable multi-effect) |
| Steam economy | ≈3.0-4.0 kg water/kg steam (with TVR) |
| Operating conditions | Vacuum operation, low boiling temperature; first effect ~80 °C -> last effect ~40 °C (typical) |
| Materials of construction | Product side SS316L; utility side SS304; PTFE/EPDM/FKM gaskets as specified |
| Surface finish | Product contact Ra ≤0.6-0.8 µm (customizable) |
| Instrumentation | Flow/level/pressure/temperature, conductivity (condensate), optional TOC for WFI plants |
| Compliance | ASME/PED vessels, GMP design, 21 CFR Part 11-ready data logging on request |
| CIP/SIP | Automated recipes with verification points and report export |
| Applications | APIs, intermediates, syrups, fermentation broths, solvent/water removal, mother liquor concentration |
Workshop & Build Quality
Advantages for Pharma Plants
- Consistent quality: Tight control of residence time and ΔT preserves critical quality attributes
- Lower utilities: Multi-effect energy cascade reduces live steam and cooling water needs
- Documentation package: DMR, weld maps, MTRs, FAT/SAT, calibration certificates, and validation support
- Easy maintenance: Accessible layouts, clean-in-place manifolds, and removable distributors
Delivery Workflow
Feasibility & lab tests → Thermal design & heat/mass balance → Pilot (optional) → Detailed engineering → Fabrication & FAT → Installation & commissioning → Performance testing → Training & lifecycle service.
About Hanpu
Hanpu specializes in energy-saving MEE/MVR evaporation and crystallization systems for pharmaceuticals, biotech, food & beverage, chemicals, and environmental applications. Our EPC delivery, hygienic design, and validation support help you operate efficiently, stay compliant, and scale with confidence.
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Get in Touch
Have questions about our products or want to discuss a custom order? Our team is ready to help you.
Company
Jiangsu Hanpu Mechanical Technology Co., Ltd
Location
Junmin Road, Huangqiao Industrial Park, Taixing, Jiangsu, China (Mainland)
Contact Person
Jim(General Director)