Alzheimer's Disease Phosphorylated TAU Protein (P-Tau) in POClia
 
It has been reported that the concentration of tau protein in the cerebrospinal fluid of patients with neurodegenerative diseases, such as Alzheimer's disease, is significantly higher than that of healthy controls, mainly from necrotic nerve cells, suggesting that tau protein is a sensitive indicator of CNS neuronal degeneration. , which can be used for the diagnosis and identification of diseases.
 
Alzheimer's disease has three typical pathological features: senile plaque (senile plaque), neurofibrillary tangles (neurofibrillary tangle, NFT) and reduced number of neurons, the main component of NFT is hyperphosphorylated tau protein. Abnormally hyperphosphorylated Tau protein forms neurofibrillary tangles with paired helical filaments (PHF) and accumulates in neurons. A large number of studies suggest that abnormal Tau protein is involved in the occurrence of neurodegeneration and learning and memory impairment in AD patients important role in development. Studies have shown that GSK-3β is associated with the phosphorylation of Tau protein, and Aβ enhances the activity of phosphorylated Tau protein.
 
 
 
EXPLANATION OF THE TEST
 
The level of phosphorylated tau protein in serum can be used as an indicator for the diagnosis of MCI, and it also has clinical significance for early AD.
 

 
 

 
Other Kind of Reagents we can provide: