Allergan Botox Injection Removing Wrinkles Botulinum Toxin

What is botulinum toxin type A, and how does it work (mechanism of action)?

OnabotulinumtoxinA is an injectable neuro-toxin, that is, a toxic chemical that blocks the ability of nerves to make muscles contract. In other words, it paralyzes muscles.

To cause muscles to contract, nerves release a chemical, acetylcholine, where they meet muscle cells. The acetylcholine attaches to receptors on the muscle cells and causes the muscle cells to contract or shorten. OnabotulinumtoxinA prevents the release of acetylcholine and thereby prevents contraction of the muscle cells. In order to affect the release of acetylcholine, onabotulinumtoxinA must be injected into the muscle. OnabotulinumtoxinA was approved by the FDA in December 1991.

The curative effect usually begins to appear 48 to 72 hours after the injection, and the facial wrinkles become shallow and flat, and the skin becomes smooth. However, due to its mechanism of action, the duration of treatment is usually 3 to 6 months, with an average of 4 months, and a very small number can be extended to 10 months or even a year.

To maintain efficacy, repeat injections should be repeated around 6 months to reduce antibody production. After 2 to 3 consecutive injections, the effect of each injection can last for 6 to 9 months, or even longer. This change process should clearly inform the subject to obtain the cooperation, which is conducive to enhancing the curative effect.

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