Name: Diethyl (tosyloxy)methylphosphonate

Other name: Diethyl (tosyloxy)methylphosphonate; Diethyl (tosyloxy)methylphosphonate; Tenofovir fumarate intermediate; (diethoxyphosphonyl)methyl 4-methylbenzenesulfonate; DESMP; Tenofovir intermediate

Diethyl p-toluenesulfonyl oxymethylphosphonate is an important intermediate for adefovir and tenofovir, which can be used in laboratory R&D process and chemical production synthesis process.

CAS: 31618-90-3

EC number: 608-653-9

Molecular formula: C12H19O6PS

Molecular weight: 322.31

InChI: 1S/C12H19O6PS/c1-4-16-19(13,17-5-2)10-18-20(14,15)12-8-6-11(3)7-9-12/h6-9H,4-5,10H2,1-3H3

Content: 99%

Physical and chemical properties:

Appearance: light yellow or colorless transparent oily liquid

Water content: less than 0.5%

Toluene: less than 1.0%

Density: 1.255g/cm³

Boiling point: 441.7℃ at 760 mmHg

Flash point: 220.9℃

Refractive index: 1.498

Handling and storage

Precautions for safe handling:

Good general ventilation should be sufficient to control airborne levels.

Normal measures for preventive fire protection. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

Conditions for safe storage: Keep container tightly closed in a dry and well-ventilated place.Store in refrigerator.

Storage incompatibilities: Store away from oxidizing agents

Application

Used in herbicides and fungicides, what is important is as an intermediate in the synthesis of nucleoside antivirals. Intermediate of Tenofovir. Such as: Tenofovir(Tenofovir) CAS NO:147127-20-6; Adefovir(Adefovir) CAS NO:106941-25-7; Adefovir Dipivoxil(Adefovir) CAS NO:142340-99-6.