Sterile Liquid Filling Machine For 30-500ml Glass And Plastic Bottles With Nitrogen Protection For Oral Liquids And Disinfectants
Sterile Liquid Filling Machine for 30–500 ml Glass & Plastic Bottles with Nitrogen Protection
This sterile liquid filling machine is a high-performance solution for 30–500 ml glass and plastic bottles, designed for oral liquids, syrups, medical disinfectants, serums, lotions, liquid soaps, and glass cleaners. With integrated nitrogen protection, it minimizes oxidation and microbial growth, helping extend product shelf life and maintain critical product stability, especially in Sterile and high-value cosmetic formulations.
Engineered for GMP- and ISO 13485-compliant sterile production, the system combines multiple filling modes, intelligent controls, and fast changeover to deliver high accuracy, low breakage, and excellent line efficiency.
Key Selling Points & Competitive Advantages
-
Wide application range
Handles 30–500 ml glass and plastic bottles, suitable for oral liquids, disinfectants, cosmetic serums, lotions, and household care liquids. -
Nitrogen protection for extended shelf life
Optional nitrogen flushing / nitrogen padding reduces headspace oxygen, protecting oxygen-sensitive products and supporting aseptic or quasi-aseptic processes. -
Multiple filling technologies in one platform
Supports normal pressure, vacuum filling, and peristaltic pump filling, ensuring stable performance for low- and high-viscosity liquids on the same line. -
High-precision, low-loss operation
- Filling accuracy up to ±1%
- Bottle breakage rate <0.5%
- Capping success rate >99%
These performance metrics reduce rework, product loss, and quality complaints.
-
Intelligent PLC control & e-records
- Touchscreen HMI for real-time control of speed, volume, and alarms
- Electronic batch and production records to support data integrity and audit trails, aligned with modern pharma and cosmetic manufacturing needs.
-
Rapid 30-minute changeover
Modular design allows change of bottle size or formula within 30 minutes, significantly reducing downtime and improving OEE (Overall Equipment Effectiveness). -
Regulatory compliance & hygienic design
- Conforms to GMP and ISO 13485 requirements
- FDA food-grade contact materials, sanitary piping, and smooth surfaces for easy cleaning and sterilization.
-
Energy-efficient, robust construction
With 9 kW total power, optimized layout and servo-driven systems, the machine offers stable output with controlled energy consumption suitable for 24/7 industrial production.
Main Technical Specifications
| Item | Specification |
|---|---|
| Application | Sterile liquid filling for oral liquids, syrups, disinfectants, serums, lotions, liquid soaps, glass cleaners |
| Bottle Type | Glass bottles, plastic bottles |
| Bottle Volume Range | 30–500 ml |
| Filling Method | Stainless steel pump or peristaltic pump (customizable) |
| Filling Modes | Normal pressure filling, vacuum filling, peristaltic filling |
| Filling Accuracy | ±1% |
| Nitrogen Protection | Optional nitrogen flushing / nitrogen padding before and/or after filling |
| Capping Performance | Capping success rate >99% |
| Bottle Breakage Rate | <0.5% |
| Control System | PLC + touchscreen HMI, real-time monitoring and electronic production records |
| Compliance | GMP, ISO 13485; contact materials meet FDA food-grade requirements |
| Total Power | 9 kW |
| Voltage / Frequency | 380 V / 50 Hz, 3-phase |
| Machine Weight | 2000 kg |
| Overall Dimensions (L×W×H) | 7600 × 1160 × 1645 mm |
| Changeover Time | ≤30 minutes for bottle type or formula change |
| Operating Mode | Fully automatic, suitable for in-line integration |
Typical Applications
-
Sterile & healthcare
- Oral liquids, syrups, pediatric formulations
- Medical disinfectants, antiseptic solutions
- Nutraceutical liquids
-
Cosmetics & personal care
- Serums, essences, toners
- Lotions and fluid emulsions
-
Household & cleaning products
- Liquid soaps and hand sanitizers
- Glass cleaners and multi-purpose cleaners
Advantages vs. Conventional Competitors
- More flexible filling options
Many standard liquid fillers
Get in Touch
Have questions about our products or want to discuss a custom order? Our team is ready to help you.

