EDTA-NAF Blood Collection Tube: Product Introduction and Core Functions

Product Positioning
The EDTA-NAF blood collection tube (grey stopper) is a specialized anticoagulant vacuum tube designed for blood glucose testing. Its core value lies in simultaneously addressing two critical issues – blood coagulation and glucose degradation – ensuring the accuracy of blood glucose test results.

Core Components and Mechanism of Action

1. EDTA (Ethylenediaminetetraacetic Acid)

   • Anticoagulant Action: Strongly chelates calcium ions (Ca²⁺) in blood, blocking the coagulation cascade and preventing blood clotting to provide liquid plasma samples.

   • Advantage: Minimally affects red blood cell morphology, preventing hemolysis or cell aggregation while maintaining blood cell integrity.

2. Sodium Fluoride (NaF)

   • Glycolysis Inhibitor:

     • Directly inhibits key glycolytic enzymes (e.g., enolase), blocking glucose metabolic pathways.

     • Reduces glucose degradation rate from 5%~7% per hour to near zero, maintaining stable glucose concentration during transport and storage (stable for 23 days at 25°C).

Product Features

• Dual-Protection Design:

  • EDTA anticoagulation + NaF glycolysis inhibition, ensuring both physical and biochemical sample stability.

• Materials and Manufacturing:

  • PET tube + medical-grade butyl rubber stopper + PP cap for high airtightness and chemical inertness, preventing additive contamination.

  • Silicone-coated interior wall minimizes cell adhesion and ensures uniform additive dispersion.

• Ready-to-Use Convenience:

  • Pre-set vacuum pressure for accurate blood volume (standard 3~5ml), enabling immediate mixing after collection.

Core Application Scenarios

1. Precision Blood Glucose Monitoring:

   • Diabetes diagnosis, oral glucose tolerance tests (OGTT), and continuous glucose tracking, preventing falsely low results due to glycolysis.

2. Specialized Test Compatibility:

   • Suitable for erythrocyte electrophoresis, glucose hemolysis tests, and other procedures requiring glycolysis inhibition.

Usage Precautions

• Contraindications:

  • Urea measurement via urease method, alkaline phosphatase (ALP), or amylase tests (NaF interferes with enzyme activity).

  • Electrolyte testing (EDTA chelation affects potassium/calcium ion measurement).

• Operational Protocol:

  • Gently invert tube 8-10 times post-collection to ensure thorough mixing of EDTA/NaF with blood.

Summary

Through dual-mechanism synergy (anticoagulation + glycolysis inhibition), the EDTA-NAF tube establishes itself as the gold-standard tool for blood glucose testing, particularly in scenarios requiring extended sample storage or transport. Its distinctive grey stopper provides immediate visual identification, ensuring reliability in critical diagnostic applications such as diabetes management.