Chiral Moisture-resistant Pyrrolidine Ester Intermediate for Organic Material Study
(S)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate is a chiral five-member nitrogen heterocyclic ester compound. It holds fixed single stereoconfiguration and mild reaction activity, with steady crystal form and low impurity content. The product is widely adopted in chiral fragment construction, asymmetric synthesis and custom fine chemical research.
| Test Index | Standard Value |
|---|---|
| Full Chemical Name | (S)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate |
| Molecular Formula | C₉H₁₇NO₃ |
| Molecular Weight | 187.24 |
| Appearance | Colorless transparent viscous liquid |
| Optical Purity | ≥99% ee |
| Refractive Index | 1.462~1.468 (25℃) |
| Usable Purity | 98%, 99% |
| Storage Feature | Sensitive to humid air |
The pyrrolidine ring maintains fixed S stereostructure under normal processing temperature, no racemization during common synthetic reactions to guarantee consistent optical performance.
The terminal hydroxyl group can carry out esterification and etherification under mild conditions, serving as accessible active site for deriving complex heterocyclic molecules.
Mixes uniformly with common polar organic solvents; immiscible with water and alkane medium, matching general organic synthesis process systems.
Tert-butyl carbamate protecting group effectively locks ring stereoconformation, resisting structural inversion under conventional heating below 105℃.
Continuous purification process stabilizes optical purity and composition across batches, lowering deviation of lab synthesis test data.
Complete molecular structure keeps intact below 105℃; long heating above 180℃ triggers partial deprotection decomposition.
Contact with excessive water vapor slowly reduces optical purity, requiring airtight sealed packaging during preservation and transportation.
Tert-butoxycarbonyl group can be removed under weak acidic conditions, offering flexible routes for subsequent molecular modification.
- Chiral building unit for five-member nitrogen heterocycle derivation
- Raw material for asymmetric organic synthesis and stereochemistry laboratory exploration
- Precursor for constructing multi-substituted pyrrolidine structural fragments
- Custom fine chemical intermediate for chiral material preparation
Seal inside airtight containers and store under constant low temperature dry environment. Isolate from humid air, strong acid and high temperature sources. Shorten packaging opening time to reduce moisture contact.
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