5-Amino-1MQ 98% Purity NNMT Inhibitor Metabolic Health Research

1. Product Description

• 5-Amino-1MQ (CAS: 42464-96-0) is a high-selectivity research-grade small-molecule NNMT inhibitor, widely applied in cellular metabolism regulation, body composition optimization and longevity anti-aging research. As a core targeted metabolic regulatory raw material, it precisely acts on nicotinamide N-methyltransferase to block abnormal metabolic methylation consumption. Different from ordinary energy metabolism ingredients, it fundamentally elevates intracellular NAD+ levels, activates mitochondrial energy circulation and optimizes fat metabolism balance. Featuring stable molecular structure, ultra-high target selectivity and low impurity quality, it effectively improves age-related metabolic decline, excessive fat accumulation and mitochondrial dysfunction. It is a key experimental raw material for nutraceutical formula development, cell mechanism research and anti-aging metabolic intervention projects.

2. Product Features

• Ultra-High NNMT Target Selectivity: 5-Amino-1MQ serves as a competitive substrate-site inhibitor with stable IC50 activity value, specifically inhibiting NNMT enzyme activity without interfering with other methyltransferases and NAD+ salvage pathway enzymes. It avoids off-target effects and ensures precise and targeted metabolic regulation.
• Endogenous NAD+ Elevation Characteristic: Effectively blocks NNMT-mediated nicotinamide methylation consumption, retains intracellular nicotinamide resources, continuously elevates endogenous NAD+ concentration, and activates downstream energy metabolism and anti-aging signal pathways.
• Dual Regulation of Fat & Lean Mass Metabolism: Possesses unique metabolic regulation properties of inhibiting lipogenesis and promoting fat oxidation. It reduces excessive adipose tissue accumulation while protecting lean muscle mass, realizing healthy body composition optimization without muscle loss.
• Stable Small-Molecule Physicochemical Properties: The compound features stable molecular structure, low hygroscopicity and excellent water solubility. It maintains stable biological activity under conventional experimental and formula deployment conditions, with good repeatability of experimental data.
• High-Purity Research-Grade Quality: Adopts precision chemical synthesis and multi-stage purification technology, with strictly controlled residual impurities, heavy metals and endotoxin indicators. Batch quality is stable and uniform, fully meeting cell experiments, animal research and formula development standards.

3. Technical Principle

• Precise NNMT Enzyme Activity Blocking Mechanism: NNMT is a key enzyme leading to intracellular NAD+ depletion and metabolic imbalance. 5-Amino-1MQ competitively binds to the active site of NNMT, effectively inhibiting enzyme catalytic activity, cutting off abnormal nicotinamide methylation metabolism, and reducing invalid consumption of intracellular metabolic substrates.
• NAD+ Salvage Pathway Activation: By inhibiting NNMT overactivity, it reserves sufficient nicotinamide precursors, accelerates the circulation efficiency of the NAD+ salvage pathway, significantly increases intracellular NAD+ content, and provides core coenzyme support for mitochondrial energy metabolism.
• Sirtuin Signaling Pathway Activation: Elevated NAD+ level activates SIRT1 and SIRT3 family protein activity, participates in DNA damage repair, oxidative stress resistance and cellular senescence regulation, delays age-related metabolic function decline, and improves cell anti-aging vitality.
• Mitochondrial Function Optimization: Promotes mitochondrial biogenesis and oxidative phosphorylation efficiency, enhances cellular energy expenditure and thermogenesis, reduces reactive oxygen species accumulation caused by mitochondrial dysfunction, and reverses senescent cell energy metabolism disorder.
• Adipose Metabolism Balance Regulation: Inhibits excessive differentiation and lipid storage of adipocytes, accelerates fatty acid oxidation and fat mobilization, improves insulin sensitivity and systemic lipid metabolism level, and realizes metabolic rejuvenation of adipose tissue.

4. Technical Parameters