Keypath p16/Ki-67 Immunoassay Test Kit (ICC)

Product Introduction

p16/Ki-67 dual staining reagent is an important marker for cervical cancer screening and diagnosis, which is a new detection method joint recommended by CAP and ASCCP, also recommended by Bethesda Version 2015.

Theory

• p16 causes cell cycle arrest
• Ki-67 markers cell proliferation
• Simultaneous expression of both indicates cell cycle disorders and canceration.

Result Interpretation

Nucleus of the cell is stained burgundy and cytoplasm is brown or tan.

Advantages

• High sensitivity, High Specificity
• With p16 signal at nucleus and cytoplasm, Ki-67 signal at nucleus, staining result will be clear enough for interpretation, avoiding to judge cancerous cells by Morphology.
• Reducing waste of resources and avoiding potential hazard by over diagnosis.
• Reducing workload, improve image reading efficiency, and identify risk of pathological changes.
• Effectively reducing the missed diagnosis rate of HSIL and reducing/avoiding unnecessary colposcopy.

Staining Method