Procollagen I of Aminoterminal Propeptide（PINP)for Automatic immunoassay analyzer in Bone Metabolism

Procollagen I of Aminoterminal Propeptide(PINP)for Automatic immunoassay analyzer in Bone Metabolism

Bone type I collagen is the most abundant form of collagen in the body, comprising approximately 90% of bone mass.

Type I collagen is mainly synthesized in bone tissue. Procollagen is synthesized first. There is an extension peptide at the amino N-terminus and C-terminus of type I procollagen, which are respectively called Type I procollagen N-terminal propeptide (PINP). and type I procollagen C-terminal propeptide (PICP); when type I procollagen is secreted out of the cell by osteoblasts, the N-terminal and C-terminal extended peptides are cleaved by proteases, and in addition to a small amount deposited in the bone matrix, a large amount of It enters the blood circulation and is eventually metabolized and eliminated by the liver. Therefore, under the exclusion of liver disease, the detection of PINP content in blood can accurately reflect the activity of osteoblasts, which in turn reflects the intensity of bone metabolism in the body, and guides the diagnosis and treatment of diseases caused by abnormal bone metabolism.