Cosmetics Grade Anti Aging Ergothioneine Antioxidant White Powder

Cosmetics Grade Best Anti - aging Antioxidant White Powder CAS NO 497 - 30 - 3 Ergothioneine

Product Details

Ergothioneine is a naturally occurring amino acid and is a thiourea derivative of histidine, containing a sulfur atom on the imidazole ring. This compound occurs in relatively few organisms, notably Actinobacteria, Cyanobacteria, and certain fungi. Ergothioneine was discovered in 1909 and named after the ergot fungus from which it was first purified, with its structure being determined in 1911.

In humans, ergothioneine is acquired exclusively through the diet and accumulates in erythrocytes, bone marrow, liver, kidney, seminal fluid, and eyes.In vitro, ergothioneine requires a specific transporter, ETT, also known as OCTN1 (gene symbol SLC22A4), to enter cells. Although the effect of ergothioneine in vivo is an active area of research, its physiological role in humans is undetermined. Ergothioneine is sold as a dietary supplement

Metabolism and sources

Ergothioneine has been found in bacteria, plants, and animals, sometimes at millimolar levels.Foods found to contain ergothioneine include liver, kidney, black beans, kidney bean, and oat bran, with the highest levels in bolete and oyster mushrooms. Levels can be variable, even within species and some tissues can contain much more than others. In the human body, the largest amounts of ergothioneine are found in erythrocytes, eye lens, semen,and skin.
Although many species contain ergothioneine, only a few make it; the others absorb it from their diet or, in the case of plants, from their environment.Biosynthesis has been detected in Actinobacteria, such as Mycobacterium smegmatis and certain fungi, such as Neurospora crassa.
The metabolic pathway to produce ergothioneine starts with the methylation of histidine to produce histidine betaine (hercynine). The sulfur atom is then incorporated from cysteine.The biosynthetic genes of ergothioneine have been described in Mycobacterium smegmatis, Neurospora crassa, and Schizosaccharomyces pombe.
Other species of bacteria, such as Bacillus subtilis, Escherichia coli, Proteus vulgaris, and Streptococcus, as well as fungi in the Saccharomycotina cannot make ergothioneine.

Structure
Ergothioneine is a thiourea derivative of the betaine of histidine and contains a sulfur atom bonded to the 2-position of the imidazole ring. Typical of thioureas, ergothioneine is less reactive than typical thiols such as glutathione towards alkylating agents like maleimides. It also resists oxidation by air. However, ergothioneine can be slowly oxidized over several days to the disulfide form in acidic solutions.

Function:

1. Super anti-oxidant ability, can effectively scavenge a variety of free radicals

2. Accelerate fat oxidation reaction

3. Protect mitochondria from damage

4. Resist the damage of ozone to cells

5, Protect DNA from UV-A damage

6. Inhibit the expression of TNF-α and MMP-1 to prevent photoaging

7. Anti-aging, prevent various diseases

8. Cell freshness agent

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Packaging Details

1kg/bag or according to your requirements.
25kgs/drum or according to your requirements.