Sodium Hyaluronate Molecular Weight Grades LMW MMW HMW Moisturizer Deep Penetration Anti-Aging Cosmetic Raw Ingredient

Sodium Hyaluronate is available in a range of molecular weight grades that dramatically influence its functional performance in cosmetic and medical formulations. This product line encompasses Low Molecular Weight (LMW: 10-100 kDa), Medium Molecular Weight (MMW: 500-1000 kDa), and High Molecular Weight (HMW: 1.5-3.0 MDa) Sodium Hyaluronate, each engineered to deliver distinct rheological and biological properties. Selecting the correct molecular weight is critical for achieving target formulation viscosity, skin penetration depth, and moisturization longevity.

• Tailored Viscosity Control: HMW grades provide superior thickening and film-forming for long-lasting hydration, while LMW grades penetrate deeper into the epidermis for intracellular moisture replenishment.
• Versatile Formulation Windows: Compatible with oil-in-water, water-in-oil, and gel-based systems across pH 4.0-8.0, making it an indispensable humectant for diverse product types.
• Enhanced Bioavailability: Our MMW fractions display optimal balance between dermal absorption and surface retention, ideal for daily-wear serums and essences.
• Batch-to-Batch Consistency: Tight molecular weight distribution control (PDI ≤ 1.5) ensures reproducible formulation performance across production cycles.
• Multi-Source Fermentation: Produced via Streptococcus zooepidemicus fermentation with solvent-free purification, meeting ECOCERT and COSMOS natural ingredient standards.

• Anti-Aging Serums: Penetrates stratum corneum to deliver hydration directly to viable epidermis; stimulates endogenous HA production in fibroblasts.
• Eye Contour Treatments: Low viscosity allows precise application around delicate periorbital area without dragging.
• Acne-Prone Formulations: Non-comedogenic profile at low molecular weight; regulates sebum without occlusive effects.
• After-Sun Repair: Rapid penetration to soothe UV-stressed keratinocytes and restore NMF (Natural Moisturizing Factor).

• Overnight Sleeping Masks: Forms a breathable hydrating film that locks in actives for 8+ hours of continuous moisturization.
• Sunscreen Vehicles: Enhances spreadability and water-resistance of UV filters while providing non-greasy skin feel.
• Hair Conditioners and Leave-In Treatments: Deposits a weightless moisture-binding layer on hair cuticles, reducing frizz by up to 40%.
• Post-Procedure Care: Creates a protective microenvironment over micro-injured skin following chemical peels or laser treatments.

Our Sodium Hyaluronate is manufactured through a controlled bio-fermentation process: (1) Streptococcus zooepidemicus is cultured under strict aseptic conditions in glucose-rich media; (2) the fermentation broth undergoes ethanol precipitation to isolate crude Sodium Hyaluronate; (3) enzymatic hydrolysis precisely controls molecular weight reduction when targeting LMW/MMW grades; (4) multi-stage membrane filtration (0.22 μm terminal sterilization) removes bacterial endotoxins; (5) spray-drying yields a free-flowing powder with residual moisture ≤ 10%. Every batch is tested for molecular weight distribution via Gel Permeation Chromatography (GPC) and endotoxin levels via LAL assay (≤ 0.5 EU/mg).

• Triple-Grade Portfolio: Unlike suppliers offering single-grade Sodium Hyaluronate, we provide all three molecular weight ranges from one source, simplifying supply chain management.
• GPC-Verified Distribution: Each batch ships with a Gel Permeation Chromatography report showing the complete molecular weight distribution curve—not just a single viscosity value.
• Endotoxin-Controlled: LAL-tested to ≤ 0.5 EU/mg, meeting the stringent requirements for ophthalmic and injectable-grade applications.
• Technical Formulation Support: Our applications lab provides viscosity-building curves at 0.1%-2.0% concentration for each grade to guide your formulation development.