PARP Inhibitors

Chemical Information Product name:Veliparib Purity:98% min CAS NO:912444-00-9 Solubility:DMSO : ≥ 29 mg/mL (118.71 mM) Molecular Formula:C13H16N4O Package:Package according to customer requirements. Molecular Weight:244.292 Storage:Store at -20℃ Remarks Veliparib, also known as ABT-888, is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations,

Chemical Information Product name:G007-LK Purity:98% min CAS NO:1380672-07-0 Solubility:DMSO : ≥ 30 mg/mL (56.61 mM) Molecular Formula:C25H16ClN7O3S Package:Package according to customer requirements Molecular Weight:529.958 Storage:Store at -20℃ Quality control COA Remarks G007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. G007-LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM,

Chemical Information Product name:Pamiparib Purity:98.0% min CAS NO:1446261-44-4 Solubility:DMSO : 62.5 mg/mL (209.51 mM) Molecular Formula:C16H15FN4O Package:Package according to customer requirements. Molecular Weight:298.315 Storage:Store at -20℃ Remarks Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single

Chemical Information Product name:Veliparib Purity:98% min CAS NO:912444-00-9 Solubility:DMSO : ≥ 29 mg/mL (118.71 mM) Molecular Formula:C13H16N4O Package:Package according to customer requirements. Molecular Weight:244.292 Storage:Store at -20℃ Remarks Veliparib, also known as ABT-888, is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations,

Chemical Information Product name:AZD2281 Olaparib Purity:98% min CAS NO:763113-22-0 Solubility:DMSO : ≥ 33.33 mg/mL (76.72 mM) Molecular Formula:C24H23FN4O3 Package:Package according to customer requirements. Molecular Weight:434.46 Storage:Store at -20℃ Quality control COA Remarks Olaparib (AZD-2281, trade name Lynparza) is an FDA-approved targeted therapy for cancer, developed by KuDOS Pharmaceuticals and later by AstraZeneca. It is a PARP inhibitor, inhibiting poly ADP

Chemical Information Product name:Rucaparib Purity:98% min CAS NO:283173-50-2 Solubility:DMSO : 50 mg/mL (154.63 mM) Molecular Formula:C19H18FN3O Package:Package according to customer requirements Molecular Weight:323.364 Storage:Store at -20℃ Remarks Rucaparib is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA

Chemical Information Product name:XAV-939 Purity:98% min CAS NO:284028-89-3 Solubility:DMSO : 21.5 mg/mL (68.84 mM) Molecular Formula:C14H11F3N2OS Package:Package according to customer requirements Molecular Weight:312.310 Storage:Store at -20℃ Remarks XAV-939 is a Tankyrase (TNKS) inhibitor with potential anticancer activity. XAV-939 antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV-939 inhibits proliferation of the μ-catenin

MK4827 Niraparib PARP Inhibitors Cas 1038915-60-4 Chemical Information Product name:MK4827 Niraparib Purity:99% min CAS NO:1038915-60-4 Solubility:DMSO : ≥ 32 mg/mL (99.88 mM) Molecular Formula:C19H20N4O Package:Package according to customer requirements Molecular Weight:320.388 Storage:Store at -20℃ Remarks Niraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor that radiosensitizes human lung and breast cancer

WIKI4 PARP Inhibitors Tankyrase C29H23N5O3S Cas 838818-26-1 Chemical Information Product name:WIKI4 Purity:98% min CAS NO:838818-26-1 Solubility:DMSO : 6.8 mg/mL (13.04 mM) Molecular Formula:C29H23N5O3S Package:Package according to customer requirements Molecular Weight:521.59 Storage:-20°C Remarks WIKI4 is a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in

AZD2461 PARP Inhibitors Cas 1174043-16-3 for Solid Tumors Chemical Information Product name:AZD2461 Purity:98% min CAS NO:1174043-16-3 Solubility:DMSO : ≥ 100 mg/mL (252.89 mM) Molecular Formula:C22H22FN3O3 Package:Package according to customer requirements Molecular Weight:395.427 Storage:Store at -20℃ Remarks AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein. AZD2641 is currently in Phase I clinical study. The study is being conducted to see

PJ34 HCl PARP Inhibitors Cas 344458-15-7 With Potential Anticancer Chemical Information Product name:PJ34 HCl Purity:98.0% min CAS NO:344458-15-7 Solubility:H2O : ≥ 6 mg/mL (18.08 mM) Molecular Formula:C17H17ClN2O2 Package:Package according to customer requirements. Molecular Weight:316.782 Storage:Store at -20℃ Quality control COA Remarks PJ-34 is a novel and potent PARP-1 inhibitor with potential anticancer activity. PJ34 has a high affinity for PARP-1 (IC(50) = 20 nM). PJ

Chemical Information Product name:Saroglitazar Purity:99% min CAS NO:495399-09-2 Solubility:DMSO : ≥ 25 mg/mL (56.87 mM) Molecular Formula:C25H29NO4S Package:Package according to customer requirements Molecular Weight:439.567 Storage:Store at -20℃ Remarks Saroglitazar is a drug for the treatment of type 2 diabetes mellitus and dyslipidemia. It is approved for use in India by the Drug Controller General of India. Saroglitazar has demonstrated reduction of triglycerides (TG),

Chemical Information Product name:Veliparib hcl Purity:98% min CAS NO:912445-05-7 Solubility:DMSO : ≥ 3.2 mg/mL (10.09 mM) Molecular Formula:C13H18Cl2N4O Package:Package according to customer requirements Molecular Weight:317.214 Storage:Store at -20℃ Remarks Veliparib, also known as ABT-888, is a potent and selective Poly (ADP-Ribose) Polymerase (PARP) Inhibitor. Veliparib enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation

Chemical Information Product name:A-966492 Purity:98% min CAS NO:934162-61-5 Solubility:DMSO : ≥ 100 mg/mL (308.31 mM) Molecular Formula:C18H17FN4O Package:Package according to customer requirements Molecular Weight:324.352 Storage:Store at -20℃ Remarks A-966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP-1 enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, A-966492 is orally bioavailable across multiple