G007-LK Inhibitor Cas 1380672-07-0
Chemical Information
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Product name:G007-LK |
Purity:98% min |
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CAS NO:1380672-07-0 |
Solubility:DMSO : ≥ 30 mg/mL (56.61 mM) |
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Molecular Formula:C25H16ClN7O3S |
Package:Package according to customer requirements |
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Molecular Weight:529.958 |
Storage:Store at -20℃ |
Quality control
Remarks
G007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. G007-LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007-LK was first discovered by Dr. Stefan Krauss's team.
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References
[1]. Voronkov A, et al. Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor. J Med Chem. 2013 Apr 11;56(7):3012-23.
[2]. Norum JH, et al. The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology. Biol Res. 2018 Jan 9;51(1):3.
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