DNA Synthesis Inhibitors

Chemical Information Product name:RKI-1447 Purity:98% min CAS NO:1342278-01-6 Solubility:DMSO : ≥ 50 mg/mL (153.20 mM) Molecular Formula:C16H14N4O2S Package:Package according to customer requirements. Molecular Weight:326.373 Storage:Store at -20℃ Quality control COA Remarks RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. RKI-1447 is a Type I kinase inhibitor that binds the ATP binding site

Chemical Information Product name:APY29 Purity:98% min CAS NO:1216665-49-4 Solubility:DMSO : 10 mg/mL (30.09 mM) Molecular Formula:C17H16N8 Package:Package according to customer requirements Molecular Weight:332.363 Storage:Store at -20℃ Remarks APY29 is a IRE1α inhibitor. The accumulation of unfolded proteins under endoplasmic reticulum (ER) stress leads to the activation of the multidomain protein sensor IRE1α as part of the unfolded protein response (UPR). ATP-competitive

Chemical Information Product name:Rifapentine Purity:99% min CAS NO:61379-65-5 Solubility:DMSO : ≥ 50 mg/mL (57.01 mM) Molecular Formula:C47H64N4O12 Package:Package according to customer requirements Molecular Weight:877.031 Storage:Store at -20℃ Remarks Rifapentine is a rifamycin antibiotic and has been used to shorten the time required to treat tuberculosis. Properties: Appearance & Physical State: red-brown crystalline powder Density: 1.35 g/cm3 (20ºC) Melting Point: 179

Chemical Information Product name:Gemcitabine Purity:98% min CAS NO:95058-81-4 Solubility:DMSO: ≥ 103.3 mg/mL Molecular Formula:C9H11F2N3O4 Package:Package according to customer requirements Molecular Weight:263.198 Storage:Store at -20℃ Quality control COA Remarks Gemcitabine is an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate

Chemical Information Product name:Tegafur Purity:98% min CAS NO:17902-23-7 Solubility:DMSO : ≥ 48 mg/mL (239.80 mM) Molecular Formula:C8H9FN2O3 Package:Package according to customer requirements Molecular Weight:200.167 Storage:Store at -20℃ Remarks Tegafur (INN) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers. It is a component of tegafur-uracil. When metabolized, it becomes 5-FU. T egafur-uracil is a formulated therapeutic oral agent consisting of a

Chemical Information Product name:NMS-873 Purity:98% min CAS NO:1418013-75-8 Solubility:DMSO : 20.5 mg/mL (39.37 mM) Molecular Formula:C27H28N4O3S2 Package:Package according to customer requirements Molecular Weight:520.666 Storage:Store at -20℃ Remarks NMS-873 is a potent, allosteric and specific VCP inhibitor (also known as p97 inhibitor) with IC50 of 30 nM. NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death. The

Chemical Information Product name:LMK-235 Purity:98% min CAS NO:1418033-25-6 Solubility:DMSO : ≥ 30 mg/mL (101.92 mM) Molecular Formula:C15H22N2O4 Package:Package according to customer requirements. Molecular Weight:294.346 Storage:Store at -20℃ Remarks LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. LMK-235 demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and

Chemical Information Product name:CB-5083 Purity:98% min CAS NO:1542705-92-9 Solubility:DMSO : ≥ 100 mg/mL (241.86 mM) Molecular Formula:C24H23N5O2 Package:Package according to customer requirements Molecular Weight:413.472 Storage:Store at -20℃ Remarks CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and

Chemical Information Product name:NE-10790 3-PEHPC Purity:98% min CAS NO:152831-36-2 Solubility:H2O : 5 mg/mL (20.23 mM) Molecular Formula:C8H10NO6P Package:Package according to customer requirements. Molecular Weight:247.142 Storage:-20 ℃ Remarks NE10790 is a risedronate analog, which belongs to the group of phosphonocarboxylates in which one of the phosphonate groups is substituted by a carboxyl group. NE-10790 had strongly reduced binding affinity, but still retained some

Chemical Information Product name:Pixantrone Purity:98% min CAS NO:144510-96-3 Solubility:H2O : < 0.1 mg/mL (insoluble) Molecular Formula:C17H19N5O2 Package:Package according to customer requirements Molecular Weight:325.365 Storage:Store at -20℃ Remarks Pixantrone is a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in

Chemical Information Product name:ELR510444 Purity:98% min CAS NO:1233948-35-0 Solubility:DMSO : ≥ 37 mg/mL (100.42 mM) Molecular Formula:C19H16N2O2S2 Package:Package according to customer requirements Molecular Weight:368.473 Storage:Store at -20℃ Remarks ELR510444 is a potent microtube disruptor with potential anticancer activity. ELR510444 has potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and

Chemical Information Product name:Vidarabine Purity:98% min CAS NO:5536-17-4 Solubility:DMSO : 50 mg/mL (187.10 mM) Molecular Formula:C10H13N5O4 Package:Package according to customer requirements Molecular Weight:267.241 Storage:Store at -20℃ Remarks Vidarabine is an antiviral drug which is active against herpes simplex and varicella zoster viruses. The drug was originally intended as an anti-cancer drug. The anti-viral activity of vidarabine was first described by M. Privat

Chemical Information Product name:Inauhzin INZ Purity:98% min CAS NO:309271-94-1 Solubility:DMSO : 21 mg/mL (44.72 mM) Molecular Formula:C25H19N5OS2 Package:Package according to customer requirements Molecular Weight:469.581 Storage:Store at -20℃ Remarks Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin

Chemical Information Product name:Lotilaner Purity:98% min CAS NO:1369852-71-0 Solubility:DMSO : ≥ 100 mg/mL (167.57 mM) Molecular Formula:C20H14Cl3F6N3O3S Package:Package according to customer requirements. Molecular Weight:596.76 Storage:-20℃ Remarks Lotilaner is an insecticide (veterinary drug). Lotilaner acts as a potent non-competitive antagonist of insects GABACl receptors. Lotilaner efficacy was 100% within 48 h post-treatment, and at nine days post-treatment. Efficacy

Chemical Information Product name:RI-1 Purity:98% min CAS NO:415713-60-9 Solubility:DMSO : 33.33 mg/mL (92.17 mM) Molecular Formula:C14H11Cl3N2O3 Package:Package according to customer requirements Molecular Weight:361.608 Storage:Store at -20℃ Remarks RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI-1 specifically reduces

Chemical Information Product name:XL228 Purity:98% min CAS NO:898280-07-4 Solubility:DMSO : ≥ 83.33 mg/mL (190.45 mM) Molecular Formula:C22H31N9O Package:Package according to customer requirements Molecular Weight:437.541 Storage:-20℃ Remarks XL228 is a synthetic molecule that targets multiple tyrosine kinases with potential antineoplastic activity. Tyrosine kinase inhibitor XL228 binds to and inhibits the activities of multiple tyrosine kinases, such as the insulin-like

Chemical Information Product name:Pixantrone Maleate Purity:98% min CAS NO:144675-97-8 Solubility:H2O : 15.6 mg/mL (27.98 mM) Molecular Formula:C21H23N5O6 Package:Package according to customer requirements. Molecular Weight:441.437 Storage:Store at -20℃ Quality control COA Remarks Pixantrone dimaleate is a topoisomerase II inhibitor. Pixantrone induces cell death in multiple cancer cell lines independent of cell cycle perturbation, with IC50s of 37.3 nM, 126 nM and 136 nM for

Chemical Information Product name:Cladribine Purity:98% min CAS NO:4291-63-8 Solubility:DMSO : ≥ 30 mg/mL (105.01 mM) Molecular Formula:C10H12ClN5O3 Package:Packaging according to customer requirements Molecular Weight:285.69 Storage:Store at 2-8ºC Remarks Cladribine is a purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide

Chemical Information Product name:Nimustine Hydrochloride Purity:98% min CAS NO:55661-38-6 Solubility:DMSO : 62.5 mg/mL (202.17 mM) Molecular Formula:C9H13ClN6O2.HCl Package:Packaging according to customer requirements Molecular Weight:309.15 Storage:Store at -20℃ Quality control COA Remarks Nimustine Hydrochloride is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition

Chemical Information Product name:Pritelivir (BAY 57-1293) Purity:98% min CAS NO:348086-71-5 Solubility:DMSO: 80 mg/mL (198.76 mM) Molecular Formula:C18H18N4O3S2 Package:Packaging according to customer requirements Molecular Weight:402.49 Storage:Store at -20℃ Remarks Pritelivir, also known as AIC-316 and BAY 57-1293, is a potent helicase primase inhibitor. BAY 57-1293 inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by