Temozolomide cas 85622-93-1

Temozolomide (CCRG81045, NSC 362856, TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity..

Properties:

Appearance & Physical State: Off-White to Light-Pink Crystalline Solid

Density: 1.97 g/cm3

Boiling Point: 526.6ºC at 760 mmHg

Melting Point: 210-212ºC

Flash Point: 272.3ºC

Related Prodcuts:

Cisplatin; Gemcitabine HCL; Bleomycin Sulfate; Carmustine; CX-5461; Fludarabine Phosphate; Nelarabine; Cladribine; Trifluridine; Daptomycin

[1]. Tentori L, et al. Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. Blood. 2002 Mar 15;99(6):2241-4.

[2]. Perazzoli G, et al. Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression. PLoS One. 2015 Oct 8;10(10):e0140131.