unoprostone cas 120373-36-6

Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.

Properties:

Density: 1.069g/cm3

Boiling Point: 562.9ºC at 760mmHg

Flash Point: 308.3ºC

Refractive Index: 1.508

Vapor Pressure: 5.16E-15mmHg at 25°C

Prostaglandins Related Products:

TP-2(TV-EDI); Misoprostol; Ornoprostil; Epoprostenol sodium; Treprostinil; Treprostinil sodium; Isopropyl unoprostone; Cyclopropyl methyl amide; Etiproston; PPB-lactondiol

1: Yu L, Eaton AF, Yue Q, Bao HF, Ma HP, Cuppoletti J, Eaton DC. Unoprostone activation of BK (KCa1.1) channel splice variants. Biochim Biophys Acta. 2015 Nov;1848(11 Pt A):2859-67. doi: 10.1016/j.bbamem.2015.08.005. Epub 2015 Aug 13. PubMed PMID: 26277265; PubMed Central PMCID: PMC4598293.

2: Harms NV, Toris CB. Current status of unoprostone for the management of glaucoma and the future of its use in the treatment of retinal disease. Expert Opin Pharmacother. 2013 Jan;14(1):105-13. doi: 10.1517/14656566.2013.748038. Epub 2012 Nov 30. Review. PubMed PMID: 23199345.