PGF2 Alpha Synthetic Prostaglandin (+)-Cloprostenol Cas 54276-21-0

D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [³H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes.

D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch.

Related Prodcuts:

Latanoprost Lactol; Latanoprostene bunod; Misoprostol; Carboprost; Tafluprost; Dinoprostone; Dinoprost; Trometamol; Alprostadil; Bimatoprost; (+/-)-Corey lactone diol; Beraprost sodium; Limaprost; D-Cloprostenol sodium; DL-Cloprostenol sodium; D-Cloprostenol isopropyl ester; 5,6-trans-Cloprostenol; (+)-Cloprostenol; 15S-(±)-Cloprostenol; Cloprostenol

[1]. Manca R, et al. Intra-vesicle administration of D-cloprostenol for induction of abortion in mid-gestation bitches. Anim Reprod Sci. 2008 Jun;106(1-2):133-42. Epub 2007 Apr 21.

[2]. Re G, et al. Specific binding of dl-cloprostenol and d-cloprostenol to PGF2 alpha receptors in bovine corpus luteum and myometrial cell membranes. J Vet Pharmacol Ther. 1994 Dec;17(6):455-8.