Tafluprost Ethyl Ester Synthetic Prostaglandin Cas 209860-89-9

Analogs of prostaglandin F2α (PGF2α), which act primarily at the FP receptor, have been approved for the treatment of glaucoma.1,2,3,4 Tafluprost (free acid) (Item No. 10005439) is a PGF2α analog which acts as a potent FP receptor agonist (Ki = 0.4 nM).5 Tafluprost ethyl ester is a form of tafluprost which may have increased lipid solubility compared to the free acid. In addition, the ethyl ester form may demonstrate improved uptake into tissues and thus lower the effective concentration.

Related products:

Tafluprost acid; Tafluprost; Tafluprost ethyl amide; Cloprostenol; Misoprostol; Carboprost; Dinoprostone; Dinoprost; Trometamol; Alprostadil; Iloprost; Limaprost; Bimatoprost; Tafluprost intermediate

1. Parrish, R.K.,Palmberg, P. and Sheu, W.P. A comparison of latanoprost, bimatoprost, and travoprost in patients with elevated intraocular pressure: A 12-week, randomized, masked-evaluator multicenter study. American Journal of Ophthalmology 135, 688-703 (2003).

2. Ota, T.,Murata, H.,Sugimoto, E.i., et al. Prostaglandin analogues and mouse intraocular pressure: Effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation. Investigative Ophthalmology & Visual Science 46(6), 2006-2011 (2005).

3. Hommer, A. and Kimmich, F. Switching patients from preserved prostaglandin-analog monotherapy to preservative-free tafluprost. Clin.Ophthalmol. 5, 623-631 (2011).