Cas 136790-76-6 Lubiprostone RU 0211 For Soften Stool Increase Motility
Cas 136790-76-6 Lubiprostone RU 0211 For Soften Stool Increase Motility
| Product name:Lubiprostone | Purity:99% min |
| CAS NO:136790-76-6 | Solubility:DMSO : 100 mg/mL (256.11 mM) |
| Molecular Formula:C20H32F2O5 | Package:Packaging according to customer requirements |
| Molecular Weight:390.46 | Storage:Store at -20℃ |
Lubiprostone, also known as RU-0211, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).
Related Prodcuts:
(+)-Cloprostenol; Cloprostenol; Misoprostol; Carboprost; Travoprost; Tafluprost; Dinoprostone; Dinoprost; Trometamol; Alprostadil; Iloprost; Limaprost; Bimatoprost; Latanoprost; Lubiprostone hemiketal; Lubiprostone Intermediate
[1] Bijvelds MJ, et al. Gastroenterology, 2009, 137(3), 976-985.
[2] Bassil AK, et al. Br J Pharmacol, 2008, 154(1), 126-135.
[3] Moeser AJ, et al. Am J Physiol Gastrointest Liver Physiol, 2007, 292(2), G647-656.
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