EMA401 Olodanrigan cas 1316755-16-4

Name: EMA401 Olodanrigan cas 1316755-16-4
Brand: Taizhou Crene Biotechnology Co., Ltd.

Price Negotiable

Price: Negotiable

MOQ: 1g

Delivery Time: Negotiable

Brand: Crene

Product Description

Chemical Information

Product name:EMA401 Olodanrigan	Purity:98% min
CAS NO:1316755-16-4	Solubility:DMSO : ≥ 34 mg/mL (66.98 mM)
Molecular Formula:C₃₂H₂₉NO₅	Package:Package according to customer requirements
Molecular Weight:507.576	Storage:Store at -20℃

Remarks

EMA401, a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

References

[1]. Rice AS et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial. Lancet. 2014 May 10;383(9929):1637-47.

[2]. Anand U et al. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015 Jun 26;11:38.