LY-450108 cas 376594-67-1

Name: LY-450108 cas 376594-67-1
Brand: Taizhou Crene Biotechnology Co., Ltd.

Price Negotiable

Price: Negotiable

MOQ: 1g

Delivery Time: Negotiable

Brand: Crene

Product Description

Chemical Information

Product name:LY-450108	Purity:98% min
CAS NO:376594-67-1	Solubility:DMSO : ≥ 50 mg/mL (126.12 mM)
Molecular Formula:C₁₉H₂₂F₂N₂O₃S	Package:Package according to customer requirements
Molecular Weight:396.451	Storage:Store at -20℃

Remarks

LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator. IC50 value: Target: AMPA receptors mediate most of the excitatory neurotransmission and play a key role in synaptic plasticity in the mammalian central nervous system (CNS). Recent evidence has shown that in addition to modulating fast synaptic plasticity and memory processes, AMPA receptor potentiators alter downstream signalling pathways and may thereby have utility in other CNS disorders.

References

[1]. Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190.

[2]. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20.