Cas 1286770-55-5 Verubecestat MK-8931 Synthesis Inhibitors
Price:
Negotiable
MOQ:
1g
Delivery Time:
Negotiable
Brand:
Crene
Product Description
Chemical Information
| Product name:Verubecestat MK-8931 | Purity:99% min |
| CAS NO:1286770-55-5 | Solubility:Soluble in DMSO |
| Molecular Formula:C17H17F2N5O3S | Package:Packaging according to customer requirements |
| Molecular Weight:409.41 | Storage:Store at -20℃ |
Remarks
MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. target: BACE1. In vitro:MK-8931 can effectively reduce Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM. [1] Docking revealed that, with respect to their free binding energy, acylguanidine 7a has the lowest binding energy followed by MK-8931 and pioglitazone and binds significantly to β-secretase. [2]
References
[1]. Yan R Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs. Transl Neurodegener. 2016 Jul 14;5:13.
[2]. Nisha CM et al. Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase. Adv Bioinformatics. 2016 Apr 10.
Similar Products
Get in Touch
Have questions about our products or want to discuss a custom order? Our team is ready to help you.
Company
Taizhou Crene Biotechnology Co., Ltd.
Location
Add: Economic Developed Zone of Taizhou Zhejiang China.