AKTIV Akt Inhibitor IV cas 681281-88-9

Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner. Akt inhibitor IV inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC50 = 520 nM). It also reduces the growth of cancer cells (IC50 = 0.3 μM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ROS).

Chemical Name:

6-benzothiazol-2-yl-1-ethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3-phenyl-3H-benzoimidazol-1-ium iodide

Synonyms:

5-(2-BENZOTHIAZOLYL)-3-ETHYL-2-[2-(METHYLPHENYLAMINO)ETHENYL]-1-PHENYL-1H-BENZIMIDAZOLIUM IODIDE;

AKT INHIBITOR IV;

Related Products:

Alpelisib; Gedatolisib; AS-604850; CAY10505; AS-605240; Apitolisib; PIK-93; PIK-75 Hydrochloride; YM201636; ZSTK474; PI-103; PD98059; GNE-493; MTX-211; Duvelisib; TGX-221; LY294002

1: Zhao D, Chen J, Zhang Y, Liao HB, Zhang ZF, Zhuang Y, Pan MX, Tang JC, Liu R, Lei Y, Wang S, Qin XP, Feng YG, Chen Y, Wan Q. Glycine confers neuroprotection through PTEN/AKT signal pathway in experimental intracerebral hemorrhage. Biochem Biophys Res Commun. 2018 May 4. pii: S0006-291X(18)30964-1. doi: 10.1016/j.bbrc.2018.04.171. [Epub ahead of print] PubMed PMID: 29698679.

2: Liu S, Chen S, Ren J, Li B, Qin B. Ghrelin protects retinal ganglion cells against rotenone via inhibiting apoptosis, restoring mitochondrial function, and activating AKT-mTOR signaling. Neuropeptides. 2018 Feb;67:63-70. doi: 10.1016/j.npep.2017.11.007. Epub 2017 Nov 21. PubMed PMID: 29174113.