ZSTK474 Cas 475110-96-4 Phosphoinositide 3 Kinase Specific Inhibitor
ZSTK474 Cas 475110-96-4 Phosphoinositide 3 Kinase Specific Inhibitor
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Chemical Information
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Product name:ZSTK474 |
Purity:98% min |
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CAS NO:475110-96-4 |
Solubility:DMSO2 mg/mL (4.79 mM) |
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Molecular Formula:C19H21F2N7O2 |
Package:Package according to customer requirements |
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Molecular Weight:417.413 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
ZSTK474 is a novel orally applicable phosphoinositide 3-kinase-specific inhibitor that strongly inhibits cancer cell proliferation. Combination treatment using X-rays then ZSTK474 given orally for 8 days, starting 24h post-irradiation, significantly enhanced cell growth inhibition. The combined effect was also observed for clonogenic survival with continuous ZSTK474 treatment. Western blot analysis showed enhanced phosphorylation of Akt and GSK-3 by X-irradiation, whereas phosphorylation was inhibited by ZSTK474 treatment alone. Treatment with ZSTK474 after X-irradiation also inhibited phosphorylation, and remarkably inhibited xenograft tumor growth.
Related Products:
Alpelisib; Gedatolisib; AS-604850; CAY10505; AS-605240; Apitolisib; PIK-93; PIK-75 Hydrochloride; YM201636; PI-103; PD98059; GNE-493; MTX-211; AKTIV; Duvelisib; TGX-221; LY294002
References
[1].Kong D, et al. ZSTK474 is an ATP-competitive i
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