YM201636 Cas 371942-69-7 PI3K Inhibitors C25H21N7O3
YM201636 Cas 371942-69-7 PI3K Inhibitors C25H21N7O3
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Chemical Information
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Product name:YM201636 |
Purity:98% min |
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CAS NO:371942-69-7 |
Solubility:DMSO 47 mg/mL (100.54 mM) |
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Molecular Formula:C25H21N7O3 |
Package:Package according to customer requirements |
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Molecular Weight:467.479 |
Storage:Store at -20℃ |
Quality control
Remarks
YM201636 is an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, and can also halt glucose entry by insulin in adipocytes. YM201636 almost completely inhibited basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+/-4 nM for the net insulin response. Insulin-induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those required for inhibition of insulin-induced phosphorylation of Akt/PKB. In addition to PIKfyve, YM201636 also completely inhibited insulin-dependent activation of class IA PI 3-kinase.
Related Products:
Alpelisib; Gedatolisib; AS-604850; CAY10505; AS-605240; Apitolisib; PIK-93; PIK-75 Hydrochloride; ZSTK474; PI-103; PD98059; GNE-493; MTX-211; AKTIV; Duvelisib; TGX-221; LY294002
References
[1].Jefferies HB, et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep, 2008, 9(2), 164-170.
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