P110 Inhibitor PIK-75 Hydrochloride Cas 372196-77-5
P110 Inhibitor PIK-75 Hydrochloride Cas 372196-77-5
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Chemical Information
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Product name:PIK-75 Hydrochloride |
Purity:98% min |
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CAS NO:372196-77-5 |
Solubility:DMSO30 mg/mL (61.38 mM) |
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Molecular Formula:C16H15BrClN5O4S |
Package:Package according to customer requirements |
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Molecular Weight:488.743 |
Storage:Store at -20℃ |
Quality control
Remarks
PIK-75 was developed as part of a PI 3-kinase drug discovery program. PIK75 attenuates insulin stimulation of Akt/PKB in a range of cell types at 100 nM. The compound has been reported to block growth of a range of cell lines with an IC50 value in the region of 50 nM. In vivo studies have shown that PIK-75, administered at 50 mg/kg, inhibited the growth of HeLa cell xenografts in mice models.
PIK-75 Hydrochloride is a p110 inhibitor with IC50 of 5.8 nM (200-fold more potently than p110), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.
Related Products:
Alpelisib; Gedatolisib; AS-604850; CAY10505; AS-605240; Apitolisib; PIK-93; YM201636; ZSTK474; PI-103; PD98059; GNE-493; MTX-211; AKTIV; Duvelisib; TGX-221; LY294002
References
[1].Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.
[2].Zheng Z, et
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