CAS 154447-36-6 LY294002 inhibitor Phosphoinositide 3 Kinases Inhibitor
CAS 154447-36-6 LY294002 inhibitor Phosphoinositide 3 Kinases Inhibitor
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Chemical Information
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Product name:LY294002 |
Purity:98% min |
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CAS NO:154447-36-6 |
Solubility:DMSO14.9 mg/mL (48.48 mM) |
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Molecular Formula:C19H17NO3 |
Package:Package according to customer requirements |
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Molecular Weight:307.343 |
Storage:Store at -20℃ |
Quality control
Remarks
LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 M) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.
Related Products:
Alpelisib; Gedatolisib; AS-604850; CAY10505; AS-605240; Apitolisib; PIK-93; PIK-75 Hydrochloride; YM201636; ZSTK474; PI-103; PD98059; GNE-493; MTX-211; AKTIV; Duvelisib; TGX-221
References
[1].Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404(3):449-58.
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