NSC 66389 PI3K Inhibitors 3-Methyladenine Cas 5142-23-4
NSC 66389 PI3K Inhibitors 3-Methyladenine Cas 5142-23-4
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Chemical Information
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Product name:3-methyladenine |
Purity:98% min |
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CAS NO:5142-23-4 |
Solubility:DMSO22.14 mg/mL (148.44 mM) |
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Molecular Formula:C6H7N5 |
Package:Package according to customer requirements |
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Molecular Weight:149.153 |
Storage:Store at -20℃ |
Quality control
Remarks
3-Methyladenine, aslo known as NSC 66389, is an Autophagy inhibitor. 3-methyladenine enhances the sensitivity of nasopharyngeal carcinoma cells to chemotherapy and radiotherapy. 3-Methyladenine can depress drug efflux transporters via blocking the PI3K-AKT-mTOR pathway thus sensitizing MDR cancer to chemotherapy. 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells.
Related Products:
Idelalisib; Almorexant HCL; IC-87114; Pictilisib; Pictilisib mesylate; XL147; PIK-90; Omipalisib; Buparlisib; TG100-115; A66; AS-252424; GSK2636771; CH5132799; AS-604850
References
[1].Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-807.
[2].Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7(4):e35665.
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