A66 Cas 1166227-08-2 PI3K Inhibitors P110 Inhibitor
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A66 Cas 1166227-08-2 PI3K Inhibitors P110 Inhibitor
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Chemical Information
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Product name:A66 |
Purity:98% min |
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CAS NO:1166227-08-2 |
Solubility:DMSO50 mg/mL (127.06 mM) |
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Molecular Formula:C17H23N5O2S2 |
Package:Package according to customer requirements |
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Molecular Weight:393.527 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
A66 is a potent and highly selective p110 inhibitor with IC50 of 32 nM in a cell-free assay, >100 fold selectivity for p110 over other class-I PI3K isoforms. A66 blocks phosphoinositide 3-kinase signalling and tumour growth in certain cell types.
Related Products:
Idelalisib; Almorexant HCL; IC-87114; Pictilisib; Pictilisib mesylate; XL147; PIK-90; Omipalisib; Buparlisib; TG100-115; A66; AS-252424; GSK2636771; CH5132799; 3-methyladenine; AS-604850
References
[1].Jamieson S, et al. A drug targeting only p110 can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J, 2011, 438(1), 53-62.
[2].Sun M, et al. Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha. Proc Natl Acad Sci U S A, 2010, 107(35), 15547-15552.
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