FAK Inhibitors PF-00562271 Active Pharmaceutical Ingredient Cas 717907-75-0
FAK Inhibitors PF-00562271 Active Pharmaceutical Ingredient Cas 717907-75-0
| Product name:PF-00562271 | Purity:98% min |
| CAS NO:717907-75-0 | Solubility:DMSO : ≥ 48 mg/mL (94.58 mM) |
| Molecular Formula:C21H20F3N7O3S | Package:Package according to customer requirements |
| Molecular Weight:507.489 | Storage: Store at -20℃ |
PF-562271, also known as PF-562,271 and PF-271, is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. PF-562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline-rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival.
FAK Inhibitors Related Products:
PND-1186; Defactinib hydrochloride; Defactinib; PF-431396; PF-00562271 Besylate; PF-573228
[1]. Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944.
[2]. Crompton BD, et al. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res. 2013 May 1;73(9):2873-83.
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