Synthesis Akti-1 2 AKT inhibitor VIII Cas 612847-09-3
Synthesis Akti-1 2 AKT inhibitor VIII Cas 612847-09-3
+ AII PRODUCTS
- Prostaglandins - Custom Synthesis - PARP Inhibitors - PI3K Inhibitors - FAK Inhibitors - AKT Inhibitors - C-Kit Inhibitors - VEGFR Inhibitors - c-Met Inhibitors - CDK Inhibitors - CYP17 Inhibitors - DNA/RNA Inhibitors - mTOR Inhibitors - SRC Inhibitors - Others
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Chemical Information
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Product name:Akti-1/2 AKT inhibitor VIII |
Purity:98% min |
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CAS NO:612847-09-3 |
Solubility:DMSO20 mg/mL (36.26 mM); H2O< 0.1 mg/mL |
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Molecular Formula:C34H29N7O |
Package:Package according to customer requirements |
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Molecular Weight:551.64 |
Storage:Store at -20℃ |
Quality control
Remarks
AKT inhibitor VIII, also known as AKTi-1/2, is a potent, selective and ell permeable, allosteric inhibitor of Akt 1 and 2, which efficiently inhibits CaMKI activity and aryl hydrocarbon receptor pathway. AKT inhibitor VIII suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells. AKT inhibitor VIII displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, for example, calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase.
Related Products
MK-2206 2HCl; Ipatasertib; Triciribine; PHT-427; Capivasertib; Perifosine; CCT128930; AT7867; AT13148; ONC-201; SC66; Miltefosine; GSK690693
References
[1].Lindsley, et al. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg. Med. Chem. Lett. (2005), 15(3), 761-764.
[2].Zhong Z, et al. Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Both in vitro and in vivo. Cell Physiol Biochem. 2012;30(3):778-90. Epub 2012 Aug 2.
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