Taizhou Crene Biotechnology Co., Ltd.
                                                                                                           
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Chemicals Organic Intermediate
China Cas 1616632-77-9 ONC 201 TIC10 Imipridone Antitumor Therapeutic Agent for sale

Cas 1616632-77-9 ONC 201 TIC10 Imipridone Antitumor Therapeutic Agent

Price Negotiable
Price: Negotiable
MOQ: 1g
Delivery Time: Negotiable
Brand: Crene
Product Description

Cas 1616632-77-9 ONC 201 TIC10 Imipridone Antitumor Therapeutic Agent

 

Chemical Information
Product name:ONC-201 TIC10 Purity:98% min
CAS NO:1616632-77-9 Solubility:DMSO : 33.33 mg/mL (86.24 mM)
Molecular Formula:C24H26N4O Package:Package according to customer requirements
Molecular Weight:386.489 Storage:Store at -20℃
Remarks

ONC-201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.

 

 

Related Products:

MK-2206 2HCl; Ipatasertib; Triciribine; PHT-427; Capivasertib; Perifosine; CCT128930; AT7867; AT13148; ONC-201; Akti-1/2; SC66; Miltefosine; GSK690693

References
[1]. Allen JE, et al. Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects. Sci Transl Med. 2013 Feb 6;5(171):171ra17.
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Company Taizhou Crene Biotechnology Co., Ltd.
Location Add: Economic Developed Zone of Taizhou Zhejiang China.

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