Human Cancer Cell AKT Inhibitors AT7867 CAS 857531-00-1
Human Cancer Cell AKT Inhibitors AT7867 CAS 857531-00-1
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- Prostaglandins - Custom Synthesis - PARP Inhibitors - PI3K Inhibitors - FAK Inhibitors - AKT Inhibitors - C-Kit Inhibitors - VEGFR Inhibitors - c-Met Inhibitors - CDK Inhibitors - CYP17 Inhibitors - DNA/RNA Inhibitors - mTOR Inhibitors - SRC Inhibitors - Others
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Chemical Information
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Product name:AT7867 |
Purity:98% min |
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CAS NO:857531-00-1 |
Solubility:DMSO10 mg/mL (29.60 mM) |
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Molecular Formula:C20H20ClN3 |
Package:Package according to customer requirements |
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Molecular Weight:337.846 |
Storage:Store at -20℃ |
Quality control
Remarks
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. This ATP-competitive small molecule potently inhibits both AKT and p70S6K activity at the cellular level, as measured by inhibition of GSK3beta and S6 ribosomal protein phosphorylation, and also causes growth inhibition in a range of human cancer cell lines as a single agent.
Related Products
MK-2206 2HCl; Ipatasertib; Triciribine; PHT-427; Capivasertib; Perifosine; CCT128930; AT13148; ONC-201; Akti-1/2; SC66; Miltefosine; GSK690693;PF-4708671
References
[1].Grimshaw KM, et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol Cancer Ther, 2010, 9(5), 1100-1110.
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