98% Min Purity KRX 0401 Perifosine Cas 157716-52-4
98% Min Purity KRX 0401 Perifosine Cas 157716-52-4
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Chemical Information
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Product name:KRX-0401 Perifosine |
Purity:98% min |
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CAS NO:157716-52-4 |
Solubility:H2O153.33 mg/mL (332.13 mM) |
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Molecular Formula:C25H52NO4P |
Package:Package according to customer requirements. |
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Molecular Weight:461.658 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth.
This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine.
Related Products
MK-2206 2HCl; Ipatasertib; Triciribine; PHT-427; Capivasertib; CCT128930; AT7867; AT13148; ONC-201; Akti-1/2; SC66; Miltefosine; GSK690693
References
[1].Momota H, et al. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res, 2005, 65(16), 7429-7435.
[2].Vyomesh Patel, et al. Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res, 2002, 62(5), 14
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