CAS 937174-76-0 GSK690693 AKT Inhibitors Pan AKT Kinase Inhibitor
CAS 937174-76-0 GSK690693 AKT Inhibitors Pan AKT Kinase Inhibitor
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Chemical Information
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Product name:GSK690693 |
Purity:98% min |
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CAS NO:937174-76-0 |
Solubility:DMSO25 mg/mL (58.76 mM) |
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Molecular Formula:C21H27N7O3 |
Package:Package according to customer requirements |
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Molecular Weight:425.484 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
GSK690693 is a pan-AKT kinase inhibitor, is also a n aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Related Products
MK-2206 2HCl; Ipatasertib; Triciribine; PHT-427; Capivasertib; Perifosine; CCT128930; AT7867; AT13148; ONC-201; Akti-1/2; SC66; Miltefosine; Enzastaurin
References
[1].Rhodes N, et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res, 2008, 68(7), 2366-2374.
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