Antineoplastic OSI-930 C Kit Inhibitors Cas 728033-96-3
Antineoplastic OSI-930 C Kit Inhibitors Cas 728033-96-3
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Chemical Information
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Product name:OSI-930 |
Purity:98% min |
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CAS NO:728033-96-3 |
Solubility:≥22.15mg/mL in DMSO |
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Molecular Formula:C22H16F3N3O2S |
Package:Package according to customer requirements |
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Molecular Weight:443.442 |
Storage:Store at -20℃ |
Quality control
Remarks
OSI-930 is a selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI-930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c-Kit and VEGFR2 are overexpressed in a variety of cancers. Check for active clinical trials or closed clinical trials using this agent.
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Pexidartinib hcl; Pexidartinib; Telatinib; Avapritinib; Amuvatinib; DovitinibLactate; Linifanib;Crenolanib; Motesanib Diphosphate; Motesanib; Sunitinib; Imatinib mesylate; Axitinib; Masitinib; Dovitinib; ISCK03
References
[1].Garton AJ, et al. OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models. Cancer Res. 2006, 66(2):1015-1024.
[2].Lin HL, et al. Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug. Drug Metab Dispos. 2011, 39(2), 345-350.
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