Cas 796967-16-3 Linifanib ABT-869 Inhibitor Orally Bioavailable
Cas 796967-16-3 Linifanib ABT-869 Inhibitor Orally Bioavailable
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Chemical Information
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Product name:Linifanib ABT-869 |
Purity:98% min |
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CAS NO:796967-16-3 |
Solubility:DMSO72 mg/mL |
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Molecular Formula:C21H18FN5O |
Package:Packaging according to customer requirements |
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Molecular Weight:375.399 |
Storage:Store at -20℃ |
Quality control
Remarks
Linifanib, also known as ABT-869, is an orally bioavailable, small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as fms-related tyrosine kinase receptor-3 (FLT3).
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References
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[1].Albert DH, et al. Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther, 2006, 5(4), 995-1006.
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