BLU 285 Avapritinib C Kit Inhibitors Cas 1703793-34-3
Price:
Negotiable
MOQ:
1g
Delivery Time:
Negotiable
Brand:
Crene
Product Description
BLU 285 Avapritinib C Kit Inhibitors Cas 1703793-34-3
Chemical Information
| Product name:BLU-285 Avapritinib | Purity:98% min |
| CAS NO:1703793-34-3 | Solubility:DMSO : ≥ 83.33 mg/mL (167.14 mM) |
| Molecular Formula:C26H27FN10 | Package:Package according to customer requirements |
| Molecular Weight:498.558 | Storage:Store at -20℃ |
Remarks
Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM).
Related Products:
Pexidartinib hcl; Pexidartinib; Telatinib; Amuvatinib; Dovitinib Lactate; Linifanib; OSI-930; Crenolanib; Motesanib Diphosphate; Motesanib; Sunitinib; Imatinib mesylate; Axitinib; Masitinib; Dovitinib; ISCK03
References
[1]. Erica Evans, et al. Blu-285, a Potent and Selective Inhibitor for Hematologic Malignancies with KIT Exon 17 Mutations.Blood 2015 126:568.
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Company
Taizhou Crene Biotechnology Co., Ltd.
Location
Add: Economic Developed Zone of Taizhou Zhejiang China.