Pexidartinib Hydrochloride PLX3397 Pexidartinib Hcl Cas 2040295-03-0
Pexidartinib Hydrochloride PLX3397 Pexidartinib Hcl Cas 2040295-03-0
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Chemical Information
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Product name:PLX3397 Pexidartinib hcl |
Purity:98% min |
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CAS NO:2040295-03-0 |
Solubility:DMSO60 mg/mL (132.08 mM) |
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Molecular Formula:C20H16Cl2F3N5 |
Package:Package according to customer requirements |
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Molecular Weight:454.276 |
Storage:Store at -20℃ |
Quality control
Remarks
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity.
Related Products
Pexidartinib; Telatinib; Avapritinib; Amuvatinib; DovitinibLactate; Linifanib; OSI-930; Crenolanib; Motesanib Diphosphate; Motesanib; Sunitinib; Imatinib mesylate; Axitinib; Masitinib; Dovitinib; ISCK03
References
[1].DeNardo DG, et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 2011 Jun;1(1):54-67.
[2].Kuse Y, et al. Microglia increases the proliferation of retinal precursor cells during postnatal development. Mol Vis. 2018 Jul 30;24:536-545. eCollection 2018.
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