98% Min Potent C Kit Inhibitor ISCK03 Cas 945526-43-2
98% Min Potent C Kit Inhibitor ISCK03 Cas 945526-43-2
| Product name:ISCK03 | Purity:98% min |
| CAS NO:945526-43-2 | Solubility:DMSO : ≥ 38 mg/mL (106.91 mM) |
| Molecular Formula:C19H21N3O2S | Package:Package according to customer requirements |
| Molecular Weight:355.454 | Storage:Store at -20℃ |
ISCK03 is a potent c-kit inhibitor. ISCK03 inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. ISCK03 also inhibited p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. ISCK03 might be used as skin-whitening agents.
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[1]. Na YJ, et al. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. Biochem Pharmacol. 2007 Sep 1;74(5):780-6.
[2]. Hirano T, et al. Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression. Mol Cancer. 2015 Apr 19;14:90. doi: 10.1186/s12943-015-0364-7.
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