Motesanib Diphosphate C Kit Inhibitors Cas 857876-30-3
Motesanib Diphosphate C Kit Inhibitors Cas 857876-30-3
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Chemical Information
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Product name:Motesanib Diphosphate |
Purity:98% min |
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CAS NO:857876-30-3 |
Solubility:DMSO110mg/mL |
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Molecular Formula:C22H29N5O9P2 |
Package:Package according to customer requirements |
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Molecular Weight:569.441 |
Storage:Store at -20℃ |
Quality control
Remarks
Motesanib Diphosphate has broad activity against the human VEGFR family, and displays >1000 selectivity against EGFR, Src, and p38 kinase. Motesanib Diphosphate significantly inhibits VEGF-induced cellular proliferation of HUVECs with an IC50 of 10 nM, while displaying little effect at bFGF-induced proliferation with an IC50 of >3,000 nM.
Motesanib Diphosphate also potently inhibits PDGF-induced proliferation and SCF-induced c-kit phosphorylation with IC50 of 207 nM and 37 nM, respectively, but not effective against the EGF-induced EGFR phosphorylation and cell viability of A431 cells. [1] Althouth displaying little antiproliferative activity on cell growth of HUVECs alone, Motesanib Diphosphate treatment significantly sensitizes the cells to fractionated radiation.
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Pexidartinib hcl; Pexidartinib; Telatinib; Avapritinib; Amuvatinib; DovitinibLactate; Linifanib; OSI-930; Crenolanib; Motesanib; Sunitinib; Imatinib mesylate; Axitinib; Masitinib; Dovitinib; ISCK03
References
[1].Polverino A, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res. 2006 Sep 1;66(17):8715-21.
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