Sunitinib rtk inhibitor C Kit Inhibitors Cas 557795-19-4
Sunitinib rtk inhibitor C Kit Inhibitors Cas 557795-19-4
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Chemical Information
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Product name:Sunitinib |
Purity:98% min |
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CAS NO:557795-19-4 |
Solubility:DMSO25 mg/mL (62.74 mM) |
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Molecular Formula:C22H23D4FN4O2 |
Package:Package according to customer requirements |
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Molecular Weight:402.498 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
Sunitinib free base is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor. Sunitinib malate salt was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple receptor tyrosine kinases (RTKs). The simultaneous inhibition of these targets therefore reduces tumor vascularization and triggers cancer cell apoptosis and thus results in tumor shrinkage. Sunitinib also inhibits CD117 (c-KIT), the receptor tyrosine kinase that (when improperly activated by mutation) drives the majority of gastrointestinal stromal cell tumors.
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References
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