SKLB610 VEGFR Inhibitor Cas 1125780-41-7 Suppresses Human Tumor Angiogenesis
SKLB610 VEGFR Inhibitor Cas 1125780-41-7 Suppresses Human Tumor Angiogenesis
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Chemical Information
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Product name:SKLB610 |
Purity:98% min |
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CAS NO:1125780-41-7 |
Solubility:DMSO: 83 mg/mL (199.82 mM) |
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Molecular Formula:C21H16F3N3O3 |
Package:Package according to customer requirements |
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Molecular Weight:415.365 |
Storage:Store at -20℃ |
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Remarks
SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10M in biochemical kinase assays. SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity. Its potential to be a candidate of anticancer agent is worth being further investigated.
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