AL3810 E3810 Lucitanib Dual Inhibitor Cas 1058137-23-7
AL3810 E3810 Lucitanib Dual Inhibitor Cas 1058137-23-7
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Chemical Information
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Product name:E-3810 Lucitanib |
Purity:98% min |
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CAS NO:1058137-23-7 |
Solubility:DMSO25 mg/mL (56.37 mM) |
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Molecular Formula:C26H25N3O4 |
Package:Package according to customer requirements |
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Molecular Weight:443.494 |
Storage:Store at -20℃ |
Quality control
Remarks
Lucitanib , also known as E-3810 and AL3810, is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.
Related Prodcuts:
LY2874455; ZM-306416; ZM323881; Tyrphostin A9; Orantinib; Brivanib; Foretinib; SU5402; Semaxanib; SAR131675; Apatinib; SKLB610; Altiratinib; SGI-7079; AZD2932
References
[1].Bello E, et al. E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405.
[2].Colzani M
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