SAR131675 VEGFR Inhibitors Cas 1433953-83-3 Antimetastatic Activities
SAR131675 VEGFR Inhibitors Cas 1433953-83-3 Antimetastatic Activities
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Chemical Information
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Product name:SAR131675 |
Purity:98% min |
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CAS NO:1433953-83-3 |
Solubility:DMSO28 mg/mL (78.13 mM) |
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Molecular Formula:C18H22N4O4 |
Package:Package according to customer requirements |
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Molecular Weight:358.392 |
Storage:Store at -20℃ |
Quality control
Remarks
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date, displaying significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
Related Prodcuts:
LY2874455; ZM-306416; ZM323881; Tyrphostin A9; Orantinib; Brivanib; Foretinib; SU5402; Semaxanib; Lucitanib; Apatinib; SKLB610; Altiratinib; SGI-7079; AZD2932
References
[1].Alam A, et al. SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. Mol Cancer Ther. 2012 Aug;11(8):1637-49.
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