98% Min FGFR VEGFR Inhibitors SU5402 Cas 215543-92-3
98% Min FGFR VEGFR Inhibitors SU5402 Cas 215543-92-3
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Chemical Information
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Product name:SU5402 |
Purity:98% min |
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CAS NO:215543-92-3 |
Solubility:DMSO30 mg/mL (101.24 mM) |
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Molecular Formula:C17H16N2O3 |
Package:Package according to customer requirements |
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Molecular Weight:296.321 |
Storage:Store at -20℃ |
Quality control
Remarks
SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 M at VEGFR2, FGFR1, PDGFR and EGFR respectively).
Chemical Name:
3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
Properties:
Appearance & Physical State:Yellow-Green Solid
Density: 1.363g/cm3
Boiling Point: 592.6C at 760 mmHg
Melting Point: >222C (dec.)
Flash Point: 312.2C
Refractive Index: 1.688
Vapor Pressure: 6.84E-15mmHg at 25°C
Related Prodcuts:
LY2874455; ZM-306416; ZM323881; Tyrphostin A9; Orantinib; Brivanib; Foretinib; Semaxanib; SAR131675; Lucitanib; Apatinib; SKLB610; Altiratinib; SGI-7079; AZD2932
References
[1].Sun L, et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem. 1999 Dec 16;42(25):5120-30.
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