Foretinib GSK1363089 XL880 Inhibitor Cas 849217-64-7
Foretinib GSK1363089 XL880 Inhibitor Cas 849217-64-7
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Chemical Information
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Product name:Foretinib GSK1363089 |
Purity:98% min |
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CAS NO:849217-64-7 |
Solubility:DMSO38 mg/mL (60.06 mM) |
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Molecular Formula:C34H34F2N4O6 |
Package:Package according to customer requirements |
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Molecular Weight:632.654 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
Foretinib, also known as XL880 and GSK1363089, is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.
Properties:
Density: 1.372g/cm3
Boiling Point: 828.475C at 760 mmHg
Flash Point: 454.846C
Refractive Index: 1.649
Related Prodcuts:
LY2874455; ZM-306416; ZM323881; Tyrphostin A9; Orantinib; Brivanib; SU5402; Semaxanib; SAR131675; Lucitanib; Apatinib; SKLB610; Altiratinib; SGI-7079; AZD2932
References
[1].Qian F, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL
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